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Research Article

The Mosaic Genome of Anaeromyxobacter dehalogenans Strain 2CP-C Suggests an Aerobic Common Ancestor to the Delta-Proteobacteria

  • Sara H. Thomas,

    Affiliation: School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Ryan D. Wagner,

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Adrian K. Arakaki,

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Jeffrey Skolnick,

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • John R. Kirby,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

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  • Lawrence J. Shimkets,

    Affiliation: Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

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  • Robert A. Sanford,

    Affiliation: Department of Geology, University of Illinois, Urbana, Illinois, United States of America

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  • Frank E. Löffler mail

    frank.loeffler@ce.gatech.edu

    Affiliations: School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America, School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Published: May 07, 2008
  • DOI: 10.1371/journal.pone.0002103
  • Published in PLOS ONE

Reader Comments (4)

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Referee Comments: Referee 1

Posted by PLoS_ONE_Group on 13 May 2008 at 23:31 GMT

Referee 1's Review:

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N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.
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This is an excellent manuscript that sheds light in one important conundrum of evolutionary microbiology that is the diversity of metabolic pathways found often within well defined phylogenetic clusters. The manuscript is very well written and makes a very interesting contribution with very well grounded conclusions. It also shows the power of genomics when the right organisms are selected to clarify the evolution of prokaryotes. Hopefully we'll many more of these papers in the near future. I enjoyed very much reading the manuscript and recommend without hesitation to publish it in PLoS ONE