Advertisement
Research Article

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

  • Mathieu Picardeau equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

    X
  • Dieter M. Bulach equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Christiane Bouchier,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

    X
  • Richard L. Zuerner,

    Affiliation: Bacterial Diseases of Livestock Research Unit, National Animal Disease Center (NADC), Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Ames, Iowa, United States of America

    X
  • Nora Zidane,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

    X
  • Peter J. Wilson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

    X
  • Sophie Creno,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

    X
  • Elizabeth S. Kuczek,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

    X
  • Simona Bommezzadri,

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

    X
  • John C. Davis,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

    X
  • Annette McGrath,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

    X
  • Matthew J. Johnson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

    X
  • Caroline Boursaux-Eude,

    Affiliation: Plate-forme Intégration et Analyse génomique, Institut Pasteur, Paris, France

    X
  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

    X
  • Zoé Rouy,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

    X
  • Ross L. Coppel,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Julian I. Rood,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Aurélie Lajus,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

    X
  • John K. Davies,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Claudine Médigue,

    Affiliations: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France, Centre National de la Recherche Scientifique (CNRS) UMR8030, Génomique Métabolique, Evry, France

    X
  • Ben Adler mail

    *E-mail: Ben.Adler@med.monash.edu.au

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

    X
  • Published: February 13, 2008
  • DOI: 10.1371/journal.pone.0001607
  • Published in PLOS ONE

Reader Comments (2)

Post a new comment on this article

Referee comments: Referee 2

Posted by PLoS_ONE_Group on 18 Feb 2008 at 18:24 GMT

Referee 2's review:

Paper contains excellent and important data.
At table 2, I believe there is a missing line (line (1)). This table can be better formated.

At table 3, second phrase of legend, "paralogous relations between two genomes" I suggest paralogous relations (copies of genes at same genome, blue boxes).

**********
N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication the manuscript has been revised in light of these comments and to address other editorial requirements.