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Research Article

How to Turn a Genetic Circuit into a Synthetic Tunable Oscillator, or a Bistable Switch

  • Lucia Marucci,

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • David A. W. Barton,

    Affiliation: Bristol Centre for Applied Nonlinear Mathematics, University of Bristol, Bristol, United Kingdom

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  • Irene Cantone,

    Affiliation: MRC Clinical Sciences Centre Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Maria Aurelia Ricci,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Maria Pia Cosma,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Stefania Santini,

    Affiliation: Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Diego di Bernardo equal contributor mail,

    equal contributor Contributed equally to this work with: Diego di Bernardo, Mario di Bernardo

    dibernardo@tigem.it (DDB); mario.dibernardo@unina.it (MDB)

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Mario di Bernardo equal contributor mail

    equal contributor Contributed equally to this work with: Diego di Bernardo, Mario di Bernardo

    dibernardo@tigem.it (DDB); mario.dibernardo@unina.it (MDB)

    Affiliations: Department of Computer and Systems Engineering, Federico II University, Naples, Italy, Bristol Centre for Applied Nonlinear Mathematics, University of Bristol, Bristol, United Kingdom

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  • Published: December 07, 2009
  • DOI: 10.1371/journal.pone.0008083
  • Published in PLOS ONE

Reader Comments (2)

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Further information

Posted by jedsrose on 10 Dec 2009 at 17:55 GMT

The work seems indicate a new trend in the right direction. However, possibly for restrictions of article space and/or lack of further reading by me at this time, I assume that it could contain a little bit of additional information concerning specific properties of proteins and those of DNA sequences. Protein-protein interactions is a clear mention about protein properties. High Hill values also. But it does not clearly present if the oscillatory behavior is entirely based upon protein properties or it depends also on DNA sequences (except those that code the protein oscillators).

No competing interests declared.