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Research Article

Molecular Correlates of Host Specialization in Staphylococcus aureus

  • Lisa Herron-Olson,

    Affiliation: Department of Microbiology, Veterinary Pathobiology and Biomedical Genomics Center, University of Minnesota, Saint Paul, Minnesota, United States of America

    Current address: Syntiron, Saint Paul, Minnesota, United States of America

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  • J. Ross Fitzgerald,

    Affiliation: Laboratory for Bacterial Evolution and Pathogenesis, University of Edinburgh, Edinburgh, Scotland, United Kingdom

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  • James M. Musser,

    Affiliation: Center for Molecular and Translational Human Infectious Disease Research, Methodist Hospital Research Institute, and Department of Pathology, Methodist Hospital, Houston, Texas, United States of America

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  • Vivek Kapur mail

    To whom correspondence should be addressed. E-mail: vkapur@umn.edu

    Affiliation: Department of Microbiology, Veterinary Pathobiology and Biomedical Genomics Center, University of Minnesota, Saint Paul, Minnesota, United States of America

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  • Published: October 31, 2007
  • DOI: 10.1371/journal.pone.0001120
  • Published in PLOS ONE

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Academic Editor's comments and Evaluation at F1000 Biology

Posted by Academic_Editor on 06 Nov 2007 at 15:20 GMT

This article has been evaluated at and recommended by the Faculty of 1000 Biology. The full evaluation is accessible to F1000 subscribers through the link below:

http://www.f1000biology.c...


A simplified version of the evaluation is placed below for fair use.

Molecular Correlates of Host Specialization in Staphylococcus aureus.
Herron-Olson L, Fitzgerald JR, Musser JM, Kapur V
PLoS ONE 2007 2(10):e1120

Relevant Sections
GENOMICS & GENETICS > Evolutionary/comparative genetics | Genomics
MICROBIOLOGY > Applied microbiology | Cellular microbiology & pathogenesis | Medical microbiology | Microbial evolution & genomics

F1000 Factor: 9.0
Rating: Exceptional
Tags: Confirmation, New finding, Technical advance

Faculty Member: Niyaz Ahmed
Centre for DNA Fingerprinting and Diagnostics, India
MICROBIOLOGY


Faculty Comments:

The observations made in this fascinating paper confirm previous assumptions that modern bovine specialist clones diverged from a common ancestor resembling human-adapted Staphylococcus aureus clones, and have since exchanged genetic material independently of human-associated S. aureus. This paper, through a very high-profile genome data evaluation, shows how certain 'specialist' lineages of a more 'general' pathogen S. aureus, with specific predilection to cattle mammary gland niches, are beginning the transition to an intracellular lifestyle. The unexpectedly smaller genome (without much evidence of potential expansion, but with a large number of pseudo-genes in the strain ET3-1) analyzed herein highlights that the bovine associated S. aureus clones are indeed following the footsteps of Mycobacterium leprae. Apart from evolutionists, this study will be of immense significance for those in animal health and in food microbiology. The methodology part of this paper will be especially advantageous to many genome sequencing and microarray laboratories in terms of fully expanded protocols and analyses.

Competing interests: I reviewed and edited this paper for PLoS ONE.
Evaluated 6 Nov 2007

How to cite the Faculty of 1000 Biology evaluation(s) for this paper?

1) To cite all the evaluations for this article:
Faculty of 1000 Biology: evaluations for Herron-Olson L et al PLoS ONE 2007 2 (10) :e1120 http://www.f1000biology.c...
2) To cite an evaluation by a specific Faculty member:
Niyaz Ahmed: Faculty of 1000 Biology, 6 Nov 2007 http://www.f1000biology.c...