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Research Article

Insights from Amphioxus into the Evolution of Vertebrate Cartilage

  • Daniel Meulemans mail,

    To whom correspondence should be addressed. E-mail: dm@caltech.edu

    Affiliation: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

    X
  • Marianne Bronner-Fraser

    Affiliation: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

    X
  • Published: August 29, 2007
  • DOI: 10.1371/journal.pone.0000787
  • Published in PLOS ONE

Reader Comments (3)

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A great start to the discussion!

Posted by Heather on 30 Aug 2007 at 07:03 GMT

co-expression of non-secreted factors is a prerequisite for direct regulatory interactions. Thus, expression data can be used to falsify hypothetical gene regulatory interactions, such as those implicit in homology arguments.
http://plosone.org/article/info:doi/10.1371/journal.pone.0000787#article1.body1.sec3.p1

I almost want to keep these two phrases on hand to reply to those many reviewers who say "too much description, not enough functional data." This paper is a prime example of how gene expression studies are valuable and lay the groundwork for formulating and - in this case - eliminating testable hypotheses.