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Perspective

The Roots of Bioinformatics

  • David B. Searls mail

    david.b.searls@gmail.com

    Affiliation: Independent Consultant, Philadelphia, Pennsylvania, United States of America

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Additional citation

Posted by danbolser on 07 Sep 2010 at 08:06 GMT

life itself as a form of computation
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000809#article1.body1.sec2.sec1.p4

One of the best papers on the subject:

Bray D. Protein molecules as computational elements in living cells. Nature. 1995. 376:307.

http://www.ncbi.nlm.nih.gov/pubmed/7630396


Abstract:

Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures. Such proteins are functionally linked through allosteric or other mechanisms into biochemical 'circuits' that perform a variety of simple computational tasks including amplification, integration and information storage.

No competing interests declared.

RE: Additional citation

danbolser replied to danbolser on 07 Sep 2010 at 17:14 GMT

The above comment was added to the following phrase, but why would that be worth mentioning? "Still, true believers may argue that the “computational thinking” movement [4] as applied to biology, and perhaps even a view of 1life itself as a form of computation [5], ..."

No competing interests declared.