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Research Article

Adaptive Response of a Gene Network to Environmental Changes by Fitness-Induced Attractor Selection

  • Akiko Kashiwagi,

    Affiliation: Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan

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  • Itaru Urabe,

    Affiliation: Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan

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  • Kunihiko Kaneko,

    Affiliations: Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Department of Pure and Applied Sciences, The University of Tokyo, Tokyo, Japan, Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, The University of Tokyo, Tokyo, Japan

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  • Tetsuya Yomo mail

    To whom correspondence should be addressed. E-mail: yomo@ist.osaka-u.ac.jp

    Affiliations: Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Osaka University, Suita, Osaka, Japan

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000049
  • Published in PLOS ONE

Reader Comments (2)

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Very interesting article

Posted by suchire on 11 Jan 2008 at 05:29 GMT

A very insightful article on how physiological adaptation at the single-cell level can be accomplished. This has strong implications for overall evolutionary adaptation, as physiological adaptation generally enables evolutionary adaptation by mutations that fix or solidify certain physiological states.