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Research Article

An Environment-Sensitive Synthetic Microbial Ecosystem

  • Bo Hu,

    Affiliation: Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China

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  • Jin Du,

    Affiliation: Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China

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  • Rui-yang Zou,

    Affiliation: Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China

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  • Ying-jin Yuan mail

    yjyuan@tju.edu.cn

    Affiliation: Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China

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  • Published: May 12, 2010
  • DOI: 10.1371/journal.pone.0010619
  • Published in PLOS ONE

Reader Comments (1)

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Interesting model system

Posted by vshaal on 05 Jun 2010 at 18:09 GMT

I was immediately intrigued by the set-up of the experimental system (I am not familiar with microbial synthetic biology, and this is the first paper I have read in the area). The paper establishes the utility of the system and maps out the operating space of the parameters (e.g. levels of antibiotics); however, this could have been accomplished with fewer figures. Also, the paper does not flesh out the details of the system from a control/engineering point of view. Learning how to control such systems, or studying how the system is perturbed by the addition of a third bacterium, would provide the most utility in real-world applications.
In conclusion, the paper presents a potentially useful model system, though the data presented in the figures and the style of figure presentation are not particularly insightful.

No competing interests declared.