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Research Article

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

  • Tara L. Davis,

    Affiliations: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

    Current address: Molecular, Cell & Developmental Biology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, United States of America.

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  • John R. Walker,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Valérie Campagna-Slater,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Patrick J. Finerty Jr,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Ragika Paramanathan,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Galina Bernstein,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Farrell MacKenzie,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Wolfram Tempel,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Hui Ouyang,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

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  • Wen Hwa Lee,

    Affiliations: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, University of Oxford, Headington, United Kingdom

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  • Elan Z. Eisenmesser,

    Affiliation: Department of Biochemistry & Molecular Genetics, University of Colorado Denver, Aurora, Colorado, United States of America

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  • Sirano Dhe-Paganon mail

    sirano.dhepaganon@utoronto.ca

    Affiliations: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Published: July 27, 2010
  • DOI: 10.1371/journal.pbio.1000439
  • Published in PLOS Biology

About the Authors

Tara L. Davis, John R. Walker, Valérie Campagna-Slater, Patrick J. Finerty Jr, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Sirano Dhe-Paganon
Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
Tara L. Davis, Sirano Dhe-Paganon
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Wen Hwa Lee
University of Oxford, Headington, United Kingdom
Elan Z. Eisenmesser
Department of Biochemistry & Molecular Genetics, University of Colorado Denver, Aurora, Colorado, United States of America

Corresponding Author

Email: sirano.dhepaganon@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TLD EZE SDP. Performed the experiments: TLD JRW VCS PJFJ RP GB FM WT HO. Analyzed the data: TLD VCS PJFJ EZE SDP. Contributed reagents/materials/analysis tools: TLD SDP. Wrote the paper: TLD WHL EZE SDP. Assisted in editing the manuscript: JRW VCS PJF WT EZE. Designed and prepared the ICM electronic manuscript: WHL.