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Research Article

Heterotachy in Mammalian Promoter Evolution

  • Martin S Taylor,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan

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  • Chikatoshi Kai,

    Affiliation: Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan

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  • Jun Kawai,

    Affiliations: Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Piero Carninci,

    Affiliations: Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Yoshihide Hayashizaki,

    Affiliations: Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Colin A. M Semple mail

    To whom correspondence should be addressed. E-mail: colins@hgu.mrc.ac.uk

    Affiliations: Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Published: April 28, 2006
  • DOI: 10.1371/journal.pgen.0020030
  • Published in PLOS Genetics

About the Authors

Martin S Taylor
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Martin S Taylor, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Colin A. M Semple
Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan
Jun Kawai, Piero Carninci, Yoshihide Hayashizaki
Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan
Colin A. M Semple
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

Corresponding Author

Email: colins@hgu.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MST and CAMS designed the study, analysed the data, and wrote the manuscript. CK, JK, PC, and YH produced and analysed the CAGE data.