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Research Article

The APPLe Study: A Randomized, Community-Based, Placebo-Controlled Trial of Azithromycin for the Prevention of Preterm Birth, with Meta-Analysis

  • Nynke R. van den Broek,

    Affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Sarah A. White,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

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  • Mark Goodall,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

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  • Chikondi Ntonya,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

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  • Edith Kayira,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

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  • George Kafulafula †,

    † Deceased.

    Affiliation: Department of Obstetrics & Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi

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  • James P. Neilson mail

    jneilson@liv.ac.uk

    Affiliation: School of Reproductive & Developmental Medicine, University of Liverpool, Liverpool, United Kingdom

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  • Published: December 01, 2009
  • DOI: 10.1371/journal.pmed.1000191
  • Published in PLOS Medicine

About the Authors

Nynke R. van den Broek
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Sarah A. White, Mark Goodall, Chikondi Ntonya, Edith Kayira
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi
George Kafulafula
Department of Obstetrics & Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
James P. Neilson
School of Reproductive & Developmental Medicine, University of Liverpool, Liverpool, United Kingdom

Corresponding Author

Email: jneilson@liv.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: NRvdB SAW MG CN GK JPN. Agree with the manuscript's results and conclusions: NRvdB SAW MG CN EK GK JPN. Designed the experiments/the study: NRvdB JPN. Analyzed the data: NRvdB SAW. Collected data/did experiments for the study: NRvdB CN EK. Enrolled patients: CN EK. Wrote the first draft of the paper: NRvdB JPN. Contributed to the writing of the paper: SAW CN EK GK. NvdB and JPN planned the study. With SAW, they wrote the analysis plan and wrote the first draft of the manuscript. JPN performed the meta- analysis. MG, CN, and GK managed the project in Malawi. CN and EK managed the teams of research midwives in Malawi and performed the ultrasound scans.