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Research Article

Prenatal Treatment for Serious Neurological Sequelae of Congenital Toxoplasmosis: An Observational Prospective Cohort Study

  • Mario Cortina-Borja,

    Affiliation: Centre for Pediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom

    X
  • Hooi Kuan Tan,

    Affiliation: Centre for Pediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom

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  • Martine Wallon,

    Affiliation: Hospices Civils de Lyon, Service de Parasitologie, Hôpital de la Croix-Rousse, Lyon, France

    X
  • Malgorzata Paul,

    Affiliation: Department and Clinic of Tropical and Parasitic Diseases, University of Medical Sciences, Poznan, Poland

    X
  • Andrea Prusa,

    Affiliation: Medical University of Vienna, Department of Paediatrics and Adolescent Medicine, Division of Paediatric Neonatology, Intensive Care and Neuropaediatrics, Vienna, Austria

    X
  • Wilma Buffolano,

    Affiliation: Perinatal Infection Unit, Department of Pediatrics, University of Naples Federico II, Naples, Italy

    X
  • Gunilla Malm,

    Affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Division of Paediatrics, Karolinska University Hospital, Huddinge, Sweden

    X
  • Alison Salt,

    Affiliation: Wolfson Centre, UCL Institute of Child Health, London, United Kingdom

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  • Katherine Freeman,

    Affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Eskild Petersen,

    Affiliation: Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus N., Denmark

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  • Ruth E. Gilbert mail,

    r.gilbert@ich.ucl.ac.uk

    Affiliation: Centre for Pediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom

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  • for The European Multicentre Study on Congenital Toxoplasmosis (EMSCOT)

    Membership of EMSCOT is provided in the Acknowledgments.

    X
  • Published: October 12, 2010
  • DOI: 10.1371/journal.pmed.1000351
  • Published in PLOS Medicine

About the Authors

Mario Cortina-Borja, Hooi Kuan Tan, Ruth E. Gilbert
Centre for Pediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom
Martine Wallon
Hospices Civils de Lyon, Service de Parasitologie, Hôpital de la Croix-Rousse, Lyon, France
Malgorzata Paul
Department and Clinic of Tropical and Parasitic Diseases, University of Medical Sciences, Poznan, Poland
Andrea Prusa
Medical University of Vienna, Department of Paediatrics and Adolescent Medicine, Division of Paediatric Neonatology, Intensive Care and Neuropaediatrics, Vienna, Austria
Wilma Buffolano
Perinatal Infection Unit, Department of Pediatrics, University of Naples Federico II, Naples, Italy
Gunilla Malm
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Division of Paediatrics, Karolinska University Hospital, Huddinge, Sweden
Alison Salt
Wolfson Centre, UCL Institute of Child Health, London, United Kingdom
Katherine Freeman
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
Eskild Petersen
Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus N., Denmark

Corresponding Author

Email: r.gilbert@ich.ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: MC-B HKT MW MP AP WB GM AS KF EP REG. Agree with the manuscript's results and conclusions: MC-B HKT MW MP AP WB GM AS KF EP REG. Designed the experiments/the study: HKT AP AS EP REG. Analyzed the data: MC-B HKT AP KF REG. Collected data/did experiments for the study: HKT MW MP AP WB GM EP REG. Enrolled patients: MW MP AP WB GM EP. Wrote the first draft of the paper: REG. Contributed to the writing of the paper: MC-B HKT AP WB GM AS KF EP REG. Developed the models: MC-B. Responsible for data integrity: WB. Principal investigator for the study: REG.