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Review

HIV Treatment as Prevention: Considerations in the Design, Conduct, and Analysis of Cluster Randomized Controlled Trials of Combination HIV Prevention

  • Marie-Claude Boily mail,

    mc.boily@imperial.ac.uk

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom

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  • Benoît Mâsse,

    Affiliation: CHU Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada

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  • Ramzi Alsallaq,

    Affiliation: College of Nursing Global, New York University, New York, New York, United States of America

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  • Nancy S. Padian,

    Affiliations: Office of the US Global AIDS Coordinator, US Department of State, Washington, District of Columbia, United States of America, Department of Epidemiology, University of California, Berkeley, California, United States of America

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  • Jeffrey W. Eaton,

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom

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  • Juan F. Vesga,

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom

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  • Timothy B. Hallett

    Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom

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  • Published: July 10, 2012
  • DOI: 10.1371/journal.pmed.1001250
  • Published in PLOS Medicine

About the Authors

Marie-Claude Boily, Jeffrey W. Eaton, Juan F. Vesga, Timothy B. Hallett
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
Benoît Mâsse
CHU Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada
Ramzi Alsallaq
College of Nursing Global, New York University, New York, New York, United States of America
Nancy S. Padian
Office of the US Global AIDS Coordinator, US Department of State, Washington, District of Columbia, United States of America
Nancy S. Padian
Department of Epidemiology, University of California, Berkeley, California, United States of America

Corresponding Author

Email: mc.boily@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MCB TBH. Performed the experiments: TBH MCB RA JFV. Analyzed the data: TBH MCB RA JFV. Wrote the first draft of the manuscript: TBH MCB BM. Contributed to the writing of the manuscript: MCB TBH BM JWE NSP RA JFV. ICMJE criteria for authorship read and met: MCB TBH BM JWE NSP RA JFV. Agree with manuscript results and conclusions: MCB TBH BM JWE NSP RA JFV. Produced the figures: RA TBH JWE. Produced tables: JFV MCB.