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Research Article

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

  • Suman K. Vodnala,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

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  • Marcela Ferella,

    Affiliation: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden

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  • Hilda Lundén-Miguel,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

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  • Evans Betha,

    Affiliation: Tropical Diseases Research Center, Ndola Central, Ndola, Zambia

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  • Nick van Reet,

    Affiliation: Institute of Tropical Medicine, Antwerp, Belgium

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  • Daniel Ndem Amin,

    Affiliation: Department of Neurosciences, Karolinska Institute, Stockholm, Sweden

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  • Bo Öberg,

    Affiliation: Medivir AB, Huddinge, Sweden

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  • Björn Andersson,

    Affiliation: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden

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  • Krister Kristensson,

    Affiliation: Department of Neurosciences, Karolinska Institute, Stockholm, Sweden

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  • Hans Wigzell,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

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  • Martin E. Rottenberg mail

    Martin.Rottenberg@ki.se

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

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About the Authors

Suman K. Vodnala, Hilda Lundén-Miguel, Hans Wigzell, Martin E. Rottenberg
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Marcela Ferella, Björn Andersson
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Evans Betha
Tropical Diseases Research Center, Ndola Central, Ndola, Zambia
Nick van Reet
Institute of Tropical Medicine, Antwerp, Belgium
Daniel Ndem Amin, Krister Kristensson
Department of Neurosciences, Karolinska Institute, Stockholm, Sweden
Bo Öberg
Medivir AB, Huddinge, Sweden

Corresponding Author

Email: Martin.Rottenberg@ki.se

Competing Interests

HW is with a patent filed 30/11/1994 by Boston University on the use of cordycepin and deoxycoformycin for treatment of cancer and infectious diseases.

Author Contributions

Conceived and designed the experiments: KK HW MER. Performed the experiments: SKV MF HLM EB NVR DNA. Analyzed the data: SKV MF HLM EB B MER. Contributed reagents/materials/analysis tools: NVR B BA. Wrote the paper: KK HW MER.