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Research Article

Adaptive Response of a Gene Network to Environmental Changes by Fitness-Induced Attractor Selection

  • Akiko Kashiwagi,

    Affiliation: Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan

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  • Itaru Urabe,

    Affiliation: Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan

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  • Kunihiko Kaneko,

    Affiliations: Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Department of Pure and Applied Sciences, The University of Tokyo, Tokyo, Japan, Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, The University of Tokyo, Tokyo, Japan

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  • Tetsuya Yomo mail

    To whom correspondence should be addressed. E-mail: yomo@ist.osaka-u.ac.jp

    Affiliations: Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Osaka University, Suita, Osaka, Japan

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000049
  • Published in PLOS ONE

About the Authors

Akiko Kashiwagi, Tetsuya Yomo
Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan
Itaru Urabe
Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan
Kunihiko Kaneko, Tetsuya Yomo
Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
Tetsuya Yomo
Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Osaka University, Suita, Osaka, Japan
Kunihiko Kaneko
Department of Pure and Applied Sciences, The University of Tokyo, Tokyo, Japan
Kunihiko Kaneko
Complex Systems Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, The University of Tokyo, Tokyo, Japan

Corresponding Author

Email: yomo@ist.osaka-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TY AK. Performed the experiments: AK. Analyzed the data: TY AK. Wrote the paper: TY KK. Other: Overviewed the manuscript: IU.