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Research Article

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

  • Mathieu Picardeau equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • Dieter M. Bulach equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Christiane Bouchier,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Richard L. Zuerner,

    Affiliation: Bacterial Diseases of Livestock Research Unit, National Animal Disease Center (NADC), Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Ames, Iowa, United States of America

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  • Nora Zidane,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Peter J. Wilson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Sophie Creno,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Elizabeth S. Kuczek,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Simona Bommezzadri,

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • John C. Davis,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Annette McGrath,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Matthew J. Johnson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Caroline Boursaux-Eude,

    Affiliation: Plate-forme Intégration et Analyse génomique, Institut Pasteur, Paris, France

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  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Zoé Rouy,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

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  • Ross L. Coppel,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Julian I. Rood,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Aurélie Lajus,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

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  • John K. Davies,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Claudine Médigue,

    Affiliations: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France, Centre National de la Recherche Scientifique (CNRS) UMR8030, Génomique Métabolique, Evry, France

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  • Ben Adler mail

    *E-mail: Ben.Adler@med.monash.edu.au

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: February 13, 2008
  • DOI: 10.1371/journal.pone.0001607
  • Published in PLOS ONE

About the Authors

Mathieu Picardeau, Simona Bommezzadri
Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
Dieter M. Bulach, Torsten Seemann, Ross L. Coppel, Julian I. Rood, John K. Davies, Ben Adler
Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia
Dieter M. Bulach, Ross L. Coppel, Julian I. Rood, John K. Davies, Ben Adler
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia
Dieter M. Bulach, Julian I. Rood, John K. Davies, Ben Adler
Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia
Christiane Bouchier, Nora Zidane, Sophie Creno
Plate-forme Génomique, Institut Pasteur, Paris, France
Richard L. Zuerner
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center (NADC), Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Ames, Iowa, United States of America
Peter J. Wilson, Elizabeth S. Kuczek, John C. Davis, Annette McGrath, Matthew J. Johnson
Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia
Caroline Boursaux-Eude
Plate-forme Intégration et Analyse génomique, Institut Pasteur, Paris, France
Zoé Rouy, Aurélie Lajus, Claudine Médigue
Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France
Claudine Médigue
Centre National de la Recherche Scientifique (CNRS) UMR8030, Génomique Métabolique, Evry, France

Corresponding Author

Email: Ben.Adler@med.monash.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BA CB MP RZ DB PW EK AM CB-E. Performed the experiments: CM ZR NZ SC SB JD MJ AL. Analyzed the data: RC BA JR JD MP RZ DB AM TS. Wrote the paper: BA JR MP RZ DB.