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Research Article

Characterization of Clinically-Attenuated Burkholderia mallei by Whole Genome Sequencing: Candidate Strain for Exclusion from Select Agent Lists

  • Steven E. Schutzer mail,

    schutzer@umdnj.edu

    Affiliation: Department of Medicine, University of Medicine and Dentistry - New Jersey Medical School, Newark, New Jersey, United States of America

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  • Linda R. K. Schlater,

    Affiliation: United States Department of Agriculture, Ames, Iowa, United States of America

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  • Catherine M. Ronning,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • David DeShazer,

    Affiliation: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

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  • Benjamin J. Luft,

    Affiliation: Department of Medicine, State University of New York, Stony Brook, New York, United States of America

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  • John J. Dunn,

    Affiliation: Biology Department, Brookhaven National Laboratory, Upton, New York, United States of America

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  • Jacques Ravel,

    Affiliations: Institute for Genome Sciences, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Claire M. Fraser-Liggett,

    Affiliations: Institute for Genome Sciences, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • William C. Nierman

    Affiliations: J. Craig Venter Institute, Rockville, Maryland, United States of America, Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, D. C., United States of America

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  • Published: April 30, 2008
  • DOI: 10.1371/journal.pone.0002058
  • Published in PLOS ONE

About the Authors

Steven E. Schutzer
Department of Medicine, University of Medicine and Dentistry - New Jersey Medical School, Newark, New Jersey, United States of America
Linda R. K. Schlater
United States Department of Agriculture, Ames, Iowa, United States of America
Catherine M. Ronning, William C. Nierman
J. Craig Venter Institute, Rockville, Maryland, United States of America
David DeShazer
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
Benjamin J. Luft
Department of Medicine, State University of New York, Stony Brook, New York, United States of America
John J. Dunn
Biology Department, Brookhaven National Laboratory, Upton, New York, United States of America
Jacques Ravel, Claire M. Fraser-Liggett
Institute for Genome Sciences, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Jacques Ravel, Claire M. Fraser-Liggett
Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
William C. Nierman
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, D. C., United States of America

Corresponding Author

Email: schutzer@umdnj.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CF SS BL LS JD. Performed the experiments: LS WN CR. Analyzed the data: CF SS JR DD BL LS JD WN CR. Contributed reagents/materials/analysis tools: DD LS WN. Wrote the paper: CF SS DD BL LS JD WN CR. Other: Figure construction: JR.