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Research Article

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit

  • Tobias May,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Lee Eccleston,

    Affiliation: Department of Engineering, University of Cambridge, Cambridge, United Kingdom

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  • Sabrina Herrmann,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Hansjörg Hauser,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Jorge Goncalves,

    Affiliation: Department of Engineering, University of Cambridge, Cambridge, United Kingdom

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  • Dagmar Wirth mail

    dagmar.wirth@helmholtz-hzi.de

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Published: June 04, 2008
  • DOI: 10.1371/journal.pone.0002372
  • Published in PLOS ONE

About the Authors

Tobias May, Sabrina Herrmann, Hansjörg Hauser, Dagmar Wirth
Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany
Lee Eccleston, Jorge Goncalves
Department of Engineering, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: dagmar.wirth@helmholtz-hzi.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW TM LE JG. Performed the experiments: TM LE SH. Analyzed the data: DW TM HH LE JG. Wrote the paper: DW TM HH LE JG.