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Research Article

Design and Construction of a Double Inversion Recombination Switch for Heritable Sequential Genetic Memory

  • Timothy S. Ham,

    Affiliation: Department of Bioengineering, University of California, Berkeley, California, United States of America

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  • Sung K. Lee,

    Affiliation: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Jay D. Keasling,

    Affiliations: Department of Bioengineering, University of California, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Department of Chemical Engineering, University of California, Berkeley, California, United States of America

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  • Adam P. Arkin mail

    aparkin@lbl.gov

    Affiliations: Department of Bioengineering, University of California, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Published: July 30, 2008
  • DOI: 10.1371/journal.pone.0002815
  • Published in PLOS ONE

About the Authors

Timothy S. Ham, Jay D. Keasling, Adam P. Arkin
Department of Bioengineering, University of California, Berkeley, California, United States of America
Sung K. Lee, Jay D. Keasling, Adam P. Arkin
Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Jay D. Keasling
Department of Chemical Engineering, University of California, Berkeley, California, United States of America

Corresponding Author

Email: aparkin@lbl.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TSH. Performed the experiments: TSH SKL. Analyzed the data: TSH SKL JDK APA. Contributed reagents/materials/analysis tools: TSH SKL JDK APA. Wrote the paper: TSH SKL JDK APA.