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Research Article

Design Parameters to Control Synthetic Gene Expression in Escherichia coli

  • Mark Welch mail,

    mwelch@DNA20.com

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Sridhar Govindarajan,

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Jon E. Ness,

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Alan Villalobos,

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Austin Gurney,

    Affiliation: OncoMed Pharmaceuticals, Inc., Redwood City, California, United States of America

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  • Jeremy Minshull,

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Claes Gustafsson

    Affiliation: DNA2.0, Menlo Park, California, United States of America

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  • Published: September 14, 2009
  • DOI: 10.1371/journal.pone.0007002
  • Published in PLOS ONE

About the Authors

Mark Welch, Sridhar Govindarajan, Jon E. Ness, Alan Villalobos, Jeremy Minshull, Claes Gustafsson
DNA2.0, Menlo Park, California, United States of America
Austin Gurney
OncoMed Pharmaceuticals, Inc., Redwood City, California, United States of America

Corresponding Author

Email: mwelch@DNA20.com

Competing Interests

The authors declare competing financial interests: DNA2.0 performs gene design optimization as a free service with the genes that it sells. The authors also declare competing interests in the form of two pending relevant US patent applications, nos. 12/184,240 and 12/184,234. Austin Gurney declares no competing interests.

Author Contributions

Conceived and designed the experiments: MW ALG CG. Performed the experiments: MW SG. Analyzed the data: MW SG JEN JM CG. Contributed reagents/materials/analysis tools: SG JEN AV ALG. Wrote the paper: MW JM CG.