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Research Article

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

  • Alex N. Bullock,

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Santina Russo,

    Affiliation: Swiss Light Source, Paul Scherrer Institut, Villigen PSI, Switzerland

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  • Ann Amos,

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Nicholas Pagano,

    Affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, Marburg, Germany

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  • Howard Bregman,

    Affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    Current address: Amgen Inc., Cambridge, Massachusetts, United States of America

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  • Judit É. Debreczeni,

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Wen Hwa Lee,

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Frank von Delft,

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Eric Meggers,

    Affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, Marburg, Germany

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  • Stefan Knapp mail

    stefan.knapp@sgc.ox.ac.uk

    Affiliation: University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom

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  • Published: October 20, 2009
  • DOI: 10.1371/journal.pone.0007112
  • Published in PLOS ONE

About the Authors

Alex N. Bullock, Ann Amos, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Stefan Knapp
University of Oxford, Structural Genomics Consortium, Oxford, United Kingdom
Santina Russo
Swiss Light Source, Paul Scherrer Institut, Villigen PSI, Switzerland
Nicholas Pagano, Eric Meggers
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, Marburg, Germany
Howard Bregman
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: stefan.knapp@sgc.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ANB FvD EM SK. Performed the experiments: ANB SR AA NP HB JD FvD. Analyzed the data: ANB FvD EM SK. Contributed reagents/materials/analysis tools: WHL. Wrote the paper: ANB WHL SK.