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Research Article

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

  • Ewa S. Pilka equal contributor,

    equal contributor Contributed equally to this work with: Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee

    Affiliation: Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

    X
  • Frank H. Niesen equal contributor,

    equal contributor Contributed equally to this work with: Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee

    Affiliation: Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

    X
  • Wen Hwa Lee equal contributor,

    equal contributor Contributed equally to this work with: Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee

    Affiliation: Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

    X
  • Yasser El-Hawari,

    Affiliation: University of Kiel, Kiel, Germany

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  • James E. Dunford,

    Affiliation: Nuffield Department of Orthopedic Surgery, Rheumatology and Musculoskeletal Sciences, Botnar Research Center, Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

    X
  • Grazyna Kochan,

    Affiliation: Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

    X
  • Vladimir Wsol,

    Affiliation: Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic

    X
  • Hans-Joerg Martin,

    Affiliation: University of Kiel, Kiel, Germany

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  • Edmund Maser,

    Affiliation: University of Kiel, Kiel, Germany

    X
  • Udo Oppermann mail

    udo.oppermann@sgc.ox.ac.uk

    Affiliations: Structural Genomics Consortium, University of Oxford, Headington, United Kingdom, Nuffield Department of Orthopedic Surgery, Rheumatology and Musculoskeletal Sciences, Botnar Research Center, Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

    X
  • Published: October 20, 2009
  • DOI: 10.1371/journal.pone.0007113
  • Published in PLOS ONE

About the Authors

Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee, Grazyna Kochan, Udo Oppermann
Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
Yasser El-Hawari, Hans-Joerg Martin, Edmund Maser
University of Kiel, Kiel, Germany
Vladimir Wsol
Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
James E. Dunford, Udo Oppermann
Nuffield Department of Orthopedic Surgery, Rheumatology and Musculoskeletal Sciences, Botnar Research Center, Biomedical Research Unit, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: udo.oppermann@sgc.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ESP WHL UO. Performed the experiments: ESP FHN WHL YEH JED GK VW HJM. Analyzed the data: ESP FHN WHL YEH VW EM UO. Wrote the paper: EM UO.