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Research Article

How to Turn a Genetic Circuit into a Synthetic Tunable Oscillator, or a Bistable Switch

  • Lucia Marucci,

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • David A. W. Barton,

    Affiliation: Bristol Centre for Applied Nonlinear Mathematics, University of Bristol, Bristol, United Kingdom

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  • Irene Cantone,

    Affiliation: MRC Clinical Sciences Centre Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Maria Aurelia Ricci,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Maria Pia Cosma,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Stefania Santini,

    Affiliation: Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Diego di Bernardo equal contributor mail,

    equal contributor Contributed equally to this work with: Diego di Bernardo, Mario di Bernardo

    dibernardo@tigem.it (DDB); mario.dibernardo@unina.it (MDB)

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Mario di Bernardo equal contributor mail

    equal contributor Contributed equally to this work with: Diego di Bernardo, Mario di Bernardo

    dibernardo@tigem.it (DDB); mario.dibernardo@unina.it (MDB)

    Affiliations: Department of Computer and Systems Engineering, Federico II University, Naples, Italy, Bristol Centre for Applied Nonlinear Mathematics, University of Bristol, Bristol, United Kingdom

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  • Published: December 07, 2009
  • DOI: 10.1371/journal.pone.0008083
  • Published in PLOS ONE

About the Authors

Lucia Marucci, Maria Aurelia Ricci, Maria Pia Cosma, Diego di Bernardo
Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
Lucia Marucci, Stefania Santini, Diego di Bernardo, Mario di Bernardo
Department of Computer and Systems Engineering, Federico II University, Naples, Italy
David A. W. Barton, Mario di Bernardo
Bristol Centre for Applied Nonlinear Mathematics, University of Bristol, Bristol, United Kingdom
Irene Cantone
MRC Clinical Sciences Centre Faculty of Medicine, Imperial College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MPC. Performed the experiments: IC MAR MPC. Analyzed the data: lm DAWB IC. Contributed reagents/materials/analysis tools: LM DAWB. Wrote the paper: LM SS DDB MdB. Critically revised the manuscript: LM DAWB SS DDB MdB.