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Research Article

Improved Reconstruction of In Silico Gene Regulatory Networks by Integrating Knockout and Perturbation Data

  • Kevin Y. Yip,

    Affiliation: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Roger P. Alexander,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Koon-Kiu Yan,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Mark Gerstein mail

    mark.gerstein@yale.edu

    Affiliations: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pone.0008121
  • Published in PLOS ONE

About the Authors

Kevin Y. Yip, Mark Gerstein
Department of Computer Science, Yale University, New Haven, Connecticut, United States of America
Roger P. Alexander, Koon-Kiu Yan, Mark Gerstein
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Mark Gerstein
Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Corresponding Author

Email: mark.gerstein@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KYY RPA K-KY MG. Performed the experiments: KYY. Analyzed the data: KYY. Wrote the paper: KYY.