Advertisement
Research Article

A Biophysical Model for Analysis of Transcription Factor Interaction and Binding Site Arrangement from Genome-Wide Binding Data

  • Xin He,

    Affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

    X
  • Chieh-Chun Chen,

    Affiliation: Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

    X
  • Feng Hong,

    Affiliation: Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

    X
  • Fang Fang,

    Affiliation: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, Singapore

    X
  • Saurabh Sinha,

    Affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

    X
  • Huck-Hui Ng,

    Affiliation: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, Singapore

    X
  • Sheng Zhong mail

    szhong@illinois.edu

    Affiliations: Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America, Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America, Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

    X
  • Published: December 01, 2009
  • DOI: 10.1371/journal.pone.0008155
  • Published in PLOS ONE

About the Authors

Xin He, Saurabh Sinha, Sheng Zhong
Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America
Chieh-Chun Chen, Sheng Zhong
Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America
Feng Hong, Sheng Zhong
Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America
Fang Fang, Huck-Hui Ng
Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, Singapore

Corresponding Author

Email: szhong@illinois.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XH SZ. Performed the experiments: XH CCC FH FF HHN. Analyzed the data: XH CCC FH SZ. Contributed reagents/materials/analysis tools: XH CCC SS HHN. Wrote the paper: XH SS SZ.