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Research Article

Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells

  • Lukas Vrba,

    Affiliations: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Biology Centre ASCR, v.v.i., Institute of Plant Molecular Biology, Ceske Budejovice, Czech Republic

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  • Taylor J. Jensen,

    Affiliations: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

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  • James C. Garbe,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Ronald L. Heimark,

    Affiliation: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America

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  • Anne E. Cress,

    Affiliation: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America

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  • Sally Dickinson,

    Affiliation: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America

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  • Martha R. Stampfer,

    Affiliations: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Bernard W. Futscher mail

    bfutscher@azcc.arizona.edu

    Affiliations: Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

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  • Published: January 13, 2010
  • DOI: 10.1371/journal.pone.0008697
  • Published in PLOS ONE

About the Authors

Lukas Vrba, Taylor J. Jensen, Ronald L. Heimark, Anne E. Cress, Sally Dickinson, Martha R. Stampfer, Bernard W. Futscher
Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America
Taylor J. Jensen, Bernard W. Futscher
Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
James C. Garbe, Martha R. Stampfer
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Lukas Vrba
Biology Centre ASCR, v.v.i., Institute of Plant Molecular Biology, Ceske Budejovice, Czech Republic

Corresponding Author

Email: bfutscher@azcc.arizona.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LV BWF. Performed the experiments: LV TJJ. Analyzed the data: LV TJJ. Contributed reagents/materials/analysis tools: JG RRH AC SD MRS. Wrote the paper: LV MRS BWF.