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Research Article

Whole Methylome Analysis by Ultra-Deep Sequencing Using Two-Base Encoding

  • Christina A. Bormann Chung mail,

    Christina.Chung@lifetech.com

    Affiliation: Life Technologies, Foster City, California, United States of America

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  • Victoria L. Boyd,

    Affiliation: Life Technologies, Foster City, California, United States of America

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  • Kevin J. McKernan,

    Affiliation: Life Technologies, Beverly, Massachusetts, United States of America

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  • Yutao Fu,

    Affiliation: Life Technologies, Beverly, Massachusetts, United States of America

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  • Cinna Monighetti,

    Affiliation: Life Technologies, Foster City, California, United States of America

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  • Heather E. Peckham,

    Affiliation: Life Technologies, Beverly, Massachusetts, United States of America

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  • Melissa Barker

    Affiliation: Life Technologies, Foster City, California, United States of America

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  • Published: February 22, 2010
  • DOI: 10.1371/journal.pone.0009320
  • Published in PLOS ONE

About the Authors

Christina A. Bormann Chung, Victoria L. Boyd, Cinna Monighetti, Melissa Barker
Life Technologies, Foster City, California, United States of America
Kevin J. McKernan, Yutao Fu, Heather E. Peckham
Life Technologies, Beverly, Massachusetts, United States of America

Corresponding Author

Email: Christina.Chung@lifetech.com

Competing Interests

All authors are employees of Life Technologies, in which some authors may have equity and/or stock options. Life Technologies manufactures and sells the SOLiD system and reagents used to perform the global sequencing analysis provided in this manuscript. Life Technology provided the instrumentation, reagents, software and salaries to the scientists who conducted the studies. The authors' affiliation to Life Technologies does not interfer with adherence to PLos One policies on sharing data and all the materials used are commercially available. The decision to publish was a volunteer activity on the part of the authors.

Author Contributions

Conceived and designed the experiments: VLB KJM MAB. Performed the experiments: CABC VLB CKM. Analyzed the data: CABC YLF HP. Wrote the paper: CABC.