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Research Article

Gene Regulatory Networks from Multifactorial Perturbations Using Graphical Lasso: Application to the DREAM4 Challenge

  • Patricia Menéndez,

    Affiliations: Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands

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  • Yiannis A. I. Kourmpetis,

    Affiliations: Biometris, Wageningen University, Wageningen, The Netherlands, Laboratory of Bioinformatics, Wageningen University, Wageningen, The Netherlands

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  • Cajo J. F. ter Braak mail,

    cajo.terbraak@wur.nl

    Affiliation: Biometris, Wageningen University, Wageningen, The Netherlands

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  • Fred A. van Eeuwijk

    Affiliations: Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands

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  • Published: December 20, 2010
  • DOI: 10.1371/journal.pone.0014147
  • Published in PLOS ONE

About the Authors

Patricia Menéndez, Yiannis A. I. Kourmpetis, Cajo J. F. ter Braak, Fred A. van Eeuwijk
Biometris, Wageningen University, Wageningen, The Netherlands
Patricia Menéndez, Fred A. van Eeuwijk
Centre for BioSystems Genetics, Wageningen, The Netherlands
Yiannis A. I. Kourmpetis
Laboratory of Bioinformatics, Wageningen University, Wageningen, The Netherlands

Corresponding Author

Email: cajo.terbraak@wur.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PM YK CJFtB FvE. Performed the experiments: PM YK CJFtB FvE. Analyzed the data: PM YK CJFtB FvE. Contributed reagents/materials/analysis tools: PM YK CJFtB FvE. Wrote the paper: PM YK CJFtB FvE.