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Research Article

Site-Specific Integration and Expression of an Anti-Malarial Gene in Transgenic Anopheles gambiae Significantly Reduces Plasmodium Infections

  • Janet M. Meredith equal contributor,

    equal contributor Contributed equally to this work with: Janet M. Meredith, Sanjay Basu

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Sanjay Basu equal contributor,

    equal contributor Contributed equally to this work with: Janet M. Meredith, Sanjay Basu

    Affiliations: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom, Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Derric D. Nimmo,

    Affiliations: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom, Oxitec Ltd, Milton Park, Oxford, United Kingdom

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  • Isabelle Larget-Thiery,

    Affiliation: Institut Pasteur, Center for Production and Infection of Anopheles, Parasitology and Mycology Department, Paris, France

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  • Emma L. Warr,

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Ann Underhill,

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Clare C. McArthur,

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Victoria Carter,

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Hilary Hurd,

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Catherine Bourgouin,

    Affiliation: Institut Pasteur, Center for Production and Infection of Anopheles, Parasitology and Mycology Department, Paris, France

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  • Paul Eggleston mail

    p.eggleston@biol.keele.ac.uk.

    Affiliation: Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom

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  • Published: January 25, 2011
  • DOI: 10.1371/journal.pone.0014587
  • Published in PLOS ONE

About the Authors

Janet M. Meredith, Sanjay Basu, Derric D. Nimmo, Emma L. Warr, Ann Underhill, Clare C. McArthur, Victoria Carter, Hilary Hurd, Paul Eggleston
Centre for Applied Entomology and Parasitology, Keele University, Keele, United Kingdom
Sanjay Basu
Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
Derric D. Nimmo
Oxitec Ltd, Milton Park, Oxford, United Kingdom
Isabelle Larget-Thiery, Catherine Bourgouin
Institut Pasteur, Center for Production and Infection of Anopheles, Parasitology and Mycology Department, Paris, France

Corresponding Author

Email: p.eggleston@biol.keele.ac.uk.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PE. Performed the experiments: JMM SB ILT ELW AU CCM VC HH CB PE. Analyzed the data: JMM SB PE. Contributed reagents/materials/analysis tools: JMM SB DDN PE. Wrote the paper: JMM PE.