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Research Article

De Novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth

  • Michael A. Fisher,

    Affiliation: Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

    Current address: Energy Biosciences Institute, University of California, Berkeley, California, United States of America

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  • Kara L. McKinley,

    Affiliation: Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

    Current address: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Luke H. Bradley,

    Affiliation: Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

    Current address: Departments of Anatomy and Neurobiology, Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

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  • Sara R. Viola,

    Affiliation: Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

    Current address: Columbia University Medical Center, New York, New York, United States of America

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  • Michael H. Hecht mail

    hecht@princeton.edu

    Affiliation: Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Published: January 04, 2011
  • DOI: 10.1371/journal.pone.0015364
  • Published in PLOS ONE

About the Authors

Michael A. Fisher, Kara L. McKinley, Luke H. Bradley, Sara R. Viola, Michael H. Hecht
Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Corresponding Author

Email: hecht@princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAF KLM LHB SRV MHH. Performed the experiments: MAF KLM LHB SRV. Analyzed the data: MAF KLM LHB SRV MHH. Contributed reagents/materials/analysis tools: MAF KLM LHB SRV MHH. Wrote the paper: MAF KLM LHB SRV MHH.