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Research Article

A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch

  • Oliver Purcell mail,

    enoep@bristol.ac.uk

    Affiliation: Department of Engineering Mathematics, Bristol Centre for Complexity Sciences, University of Bristol, Bristol, United Kingdom

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  • Mario di Bernardo,

    Affiliations: Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom, Department of Systems and Computer Engineering, University of Naples Federico II, Napoli, Italy

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  • Claire S. Grierson,

    Affiliation: School of Biological Sciences, University of Bristol, Bristol, United Kingdom

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  • Nigel J. Savery

    Affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom

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  • Published: February 17, 2011
  • DOI: 10.1371/journal.pone.0016140
  • Published in PLOS ONE

About the Authors

Oliver Purcell
Department of Engineering Mathematics, Bristol Centre for Complexity Sciences, University of Bristol, Bristol, United Kingdom
Mario di Bernardo
Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom
Mario di Bernardo
Department of Systems and Computer Engineering, University of Naples Federico II, Napoli, Italy
Claire S. Grierson
School of Biological Sciences, University of Bristol, Bristol, United Kingdom
Nigel J. Savery
School of Biochemistry, University of Bristol, Bristol, United Kingdom

Corresponding Author

Email: enoep@bristol.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OP MdB CSG NJS. Performed the experiments: OP. Analyzed the data: OP. Wrote the paper: OP. Reviewed the manuscript: MdB CSG NJS.