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Research Article

Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway

  • Mauricio S. Antunes equal contributor,

    equal contributor Contributed equally to this work with: Mauricio S. Antunes, Kevin J. Morey

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Kevin J. Morey equal contributor,

    equal contributor Contributed equally to this work with: Mauricio S. Antunes, Kevin J. Morey

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

    X
  • J. Jeff Smith,

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

    Current address: Precision BioSciences, Durham, North Carolina, United States of America

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  • Kirk D. Albrecht,

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Tessa A. Bowen,

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

    X
  • Jeffrey K. Zdunek,

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

    X
  • Jared F. Troupe,

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Matthew J. Cuneo,

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

    Current address: National Institute of Environmental Health Sciences, Morrisville, North Carolina, United States of America

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  • Colleen T. Webb,

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Homme W. Hellinga,

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • June I. Medford mail

    June.Medford@colostate.edu

    Affiliation: Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Published: January 25, 2011
  • DOI: 10.1371/journal.pone.0016292
  • Published in PLOS ONE

About the Authors

Mauricio S. Antunes, Kevin J. Morey, Kirk D. Albrecht, Tessa A. Bowen, Jeffrey K. Zdunek, Jared F. Troupe, Colleen T. Webb, June I. Medford
Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America
J. Jeff Smith, Matthew J. Cuneo, Homme W. Hellinga
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: June.Medford@colostate.edu

Competing Interests

The authors have read the journal's policy and have the following conflicts: several authors; June Medford, Homme Hellinga, Kevin Morey, Mauricio Antunes, J. Jeff Smith are inventors on a patent application that is described in this, and other, manuscripts. The United States Patent and Trademark Office has not yet made a decision on the authors' application entitled "Biological systems input-output response system and plant sentinels"; patent application number 20090130697. In addition, June Medford and Kevin Morey are seeking to develop a company, Phytodetectors, Inc., related this work. At this time Phytodetectors Inc. has no funds, no funding, no facilities and no financial support. There was no contribution of any kind from Phytodetectors, Precision Biosciences (or any company) to the work described here. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MSA KJM JIM JJS HWH. Performed the experiments: MSA KJM KDA TAB JKZ JFT MJC JJS. Analyzed the data: MSA KJM JJS CTW JIM KDA TAB JKZ. Contributed reagents/materials/analysis tools: CTW JJS HWH JIM. Wrote the paper: MSA KJM KDA TAB JKZ JIM JJS.