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Research Article

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

  • Kelly J. Chandler mail,

    chandler.kelly@epa.gov

    Affiliations: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America, National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Marianne Barrier,

    Affiliation: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Susan Jeffay,

    Affiliation: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Harriette P. Nichols,

    Affiliation: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Nicole C. Kleinstreuer,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Amar V. Singh,

    Affiliation: Lockheed Martin, Research Triangle Park, North Carolina, United States of America

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  • David M. Reif,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Nisha S. Sipes,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Richard S. Judson,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • David J. Dix,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Robert Kavlock,

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Edward S. Hunter III,

    Affiliation: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Thomas B. Knudsen

    Affiliation: National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Published: June 07, 2011
  • DOI: 10.1371/journal.pone.0018540
  • Published in PLOS ONE

About the Authors

Kelly J. Chandler, Marianne Barrier, Susan Jeffay, Harriette P. Nichols, Edward S. Hunter III
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
Kelly J. Chandler, Nicole C. Kleinstreuer, David M. Reif, Nisha S. Sipes, Richard S. Judson, David J. Dix, Robert Kavlock, Thomas B. Knudsen
National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
Amar V. Singh
Lockheed Martin, Research Triangle Park, North Carolina, United States of America

Corresponding Author

Email: chandler.kelly@epa.gov

Competing Interests

Lockheed Martin is a contractor to the EPA. This does not alter the authors' or Lockheed Martin's adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KC MB DD RK SH TK. Performed the experiments: KC SJ HN. Analyzed the data: KC MB AS. Contributed reagents/materials/analysis tools: NK DR RJ. Wrote the paper: KC. Edited the manuscript: MB NK AS DR NS RJ DD RK SH TK.