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Research Article

Comparative Structural Analysis of Lipid Binding START Domains

  • Ann-Gerd Thorsell,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Wen Hwa Lee,

    Affiliation: Structural Genomics Consortium, University of Oxford, Headington, Oxford, United Kingdom

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  • Camilla Persson,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Marina I. Siponen,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Martina Nilsson,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Robert D. Busam,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Tetyana Kotenyova,

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Herwig Schüler mail,

    lari.lehtio@abo.fi (LL); herwig.schuler@ki.se (HS)

    Affiliation: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden

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  • Lari Lehtiö mail

    lari.lehtio@abo.fi (LL); herwig.schuler@ki.se (HS)

    Affiliations: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden, Department of Biosciences, Pharmaceutical Sciences, Åbo Akademi University, Turku, Finland

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.pone.0019521
  • Published in PLOS ONE

About the Authors

Ann-Gerd Thorsell, Camilla Persson, Marina I. Siponen, Martina Nilsson, Robert D. Busam, Tetyana Kotenyova, Herwig Schüler, Lari Lehtiö
Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden
Wen Hwa Lee
Structural Genomics Consortium, University of Oxford, Headington, Oxford, United Kingdom
Lari Lehtiö
Department of Biosciences, Pharmaceutical Sciences, Åbo Akademi University, Turku, Finland

Corresponding Authors

Competing Interests

The authors have received funding from the following commercial sources: GlaxoSmithkline, Merck & Co., Inc. and Novartis. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AGT CP MIS LL. Performed the experiments: AGT CP MS MN RDB TK LL. Analyzed the data: WHL HS LL. Wrote the paper: HS LL.