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Research Article

Modeling Disordered Regions in Proteins Using Rosetta

  • Ray Yu-Ruei Wang,

    Affiliations: Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Yan Han,

    Affiliations: Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Kristina Krassovsky,

    Affiliations: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America

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  • William Sheffler,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Michael Tyka,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • David Baker mail

    dabaker@u.washington.edu

    Affiliations: Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Published: July 29, 2011
  • DOI: 10.1371/journal.pone.0022060
  • Published in PLOS ONE

About the Authors

Ray Yu-Ruei Wang, Yan Han, David Baker
Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America
Ray Yu-Ruei Wang, Yan Han, William Sheffler, Michael Tyka, David Baker
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Yan Han, Kristina Krassovsky
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Kristina Krassovsky, David Baker
Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America
David Baker
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: dabaker@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DB. Performed the experiments: RYW YH KK Analyzed the data: RYW YH KK WS MT DB. Wrote the paper: RYW DB. Designed the software used in modeling: WS RYW YH KK MT.