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Research Article

Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

  • Christopher S. Poultney,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Glenn L. Butterfoss,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Michelle R. Gutwein,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Kevin Drew,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • David Gresham,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Kristin C. Gunsalus,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Dennis E. Shasha,

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America

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  • Richard Bonneau mail

    bonneau@nyu.edu

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America

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  • Published: September 02, 2011
  • DOI: 10.1371/journal.pone.0023947
  • Published in PLOS ONE

About the Authors

Christopher S. Poultney, Glenn L. Butterfoss, Michelle R. Gutwein, Kevin Drew, David Gresham, Kristin C. Gunsalus, Dennis E. Shasha, Richard Bonneau
Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
Dennis E. Shasha, Richard Bonneau
Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America

Corresponding Author

Email: bonneau@nyu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CSP DG GLB KD KCG DES RB. Performed the experiments: DG. Analyzed the data: CSP DES. Contributed reagents/materials/analysis tools: CSP MRG KCG DES RB. Wrote the paper: CSP DG RB.