Advertisement
Research Article

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

  • Po-Ssu Huang,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    X
  • Yih-En Andrew Ban,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    Current address: Arzeda Corporation, Seattle, Washington, United States of America

    X
  • Florian Richter,

    Affiliations: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Interdisciplinary Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America

    X
  • Ingemar Andre,

    Affiliation: Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden

    X
  • Robert Vernon,

    Affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

    X
  • William R. Schief mail,

    schief@scripps.edu (WRS); dabaker@uw.edu (DB)

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    Current address: IAVI Neutralizing Antibody Center and Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • David Baker mail

    schief@scripps.edu (WRS); dabaker@uw.edu (DB)

    Affiliations: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

    X
  • Published: August 31, 2011
  • DOI: 10.1371/journal.pone.0024109
  • Published in PLOS ONE

About the Authors

Po-Ssu Huang, Yih-En Andrew Ban, Florian Richter, William R. Schief, David Baker
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Florian Richter
Interdisciplinary Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America
Ingemar Andre
Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden
Robert Vernon
Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada
David Baker
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist. YAB currently works at Arzeda Corporation, but declares no competing interest. YAB's involvement with this project was during the time he was a postdoc at the University of Washington. His use of the method described in the manuscript will have to follow the general licensing scheme like all other commercial users.

Author Contributions

Conceived and designed the experiments: P-SH YAB WRS DB. Contributed reagents/materials/analysis tools: FR IA RV. Wrote the paper: P-SH YAB WRS DB.