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Research Article

OmniChange: The Sequence Independent Method for Simultaneous Site-Saturation of Five Codons

  • Alexander Dennig equal contributor,

    equal contributor Contributed equally to this work with: Alexander Dennig, Amol V. Shivange

    Affiliation: Lehrstuhl für Biotechnologie, RWTH Aachen University, Aachen, Germany

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  • Amol V. Shivange equal contributor,

    equal contributor Contributed equally to this work with: Alexander Dennig, Amol V. Shivange

    Affiliation: Lehrstuhl für Biotechnologie, RWTH Aachen University, Aachen, Germany

    X
  • Jan Marienhagen,

    Affiliation: Lehrstuhl für Biotechnologie, RWTH Aachen University, Aachen, Germany

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  • Ulrich Schwaneberg mail

    u.schwaneberg@biotec.rwth-aachen.de

    Affiliation: Lehrstuhl für Biotechnologie, RWTH Aachen University, Aachen, Germany

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  • Published: October 19, 2011
  • DOI: 10.1371/journal.pone.0026222
  • Published in PLOS ONE

About the Authors

Alexander Dennig, Amol V. Shivange, Jan Marienhagen, Ulrich Schwaneberg
Lehrstuhl für Biotechnologie, RWTH Aachen University, Aachen, Germany

Corresponding Author

Email: u.schwaneberg@biotec.rwth-aachen.de

Competing Interests

The authors have read the journal's policy and have the following conflicts. This study was funded by BASF Societas Europea (BASF SE). A patent (“Methods and Materials for Nucleic Acid Manipulation” and EP11 165 367.1) has been filed and given the go ahead for publication. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AD AVS JM US. Performed the experiments: AD. Analyzed the data: AD AVS JM. Contributed reagents/materials/analysis tools: AD AVS. Wrote the paper: AD JM US.