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Research Article

Incorporation of Noncanonical Amino Acids into Rosetta and Use in Computational Protein-Peptide Interface Design

  • P. Douglas Renfrew,

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Courant Institute for Mathematical Sciences, Department of Computer Science, New York, New York, United States of America

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  • Eun Jung Choi,

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Richard Bonneau,

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Courant Institute for Mathematical Sciences, Department of Computer Science, New York, New York, United States of America

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  • Brian Kuhlman mail

    bkuhlman@email.unc.edu

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: March 14, 2012
  • DOI: 10.1371/journal.pone.0032637
  • Published in PLOS ONE

About the Authors

P. Douglas Renfrew, Richard Bonneau
Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
P. Douglas Renfrew, Richard Bonneau
Courant Institute for Mathematical Sciences, Department of Computer Science, New York, New York, United States of America
Eun Jung Choi, Brian Kuhlman
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: bkuhlman@email.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PDR EJC BK. Performed the experiments: PDR EJC. Analyzed the data: PDR RB BK. Contributed reagents/materials/analysis tools: PDR EJC BK. Wrote the paper: PDR RB BK.