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Research Article

Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission

  • Dorianna Sandonà equal contributor,

    equal contributor Contributed equally to this work with: Dorianna Sandonà, Jean-Francois Desaphy

    Affiliation: Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Jean-Francois Desaphy equal contributor,

    equal contributor Contributed equally to this work with: Dorianna Sandonà, Jean-Francois Desaphy

    Affiliation: Section of Pharmacology, Department of Pharmacobiology, University of Bari, Italy

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  • Giulia M. Camerino,

    Affiliation: Section of Pharmacology, Department of Pharmacobiology, University of Bari, Italy

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  • Elisa Bianchini,

    Affiliation: Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Stefano Ciciliot,

    Affiliation: Department of Human Anatomy and Physiology, University of Padova, Italy

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  • Daniela Danieli-Betto,

    Affiliation: Department of Human Anatomy and Physiology, University of Padova, Italy

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  • Gabriella Dobrowolny,

    Affiliation: DAHFMO-Unit of Histology and Medical Embryology, Sapienza University, IIM, Rome, Italy

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  • Sandra Furlan,

    Affiliation: National Research Council, Institute of Neuroscience, Padova, Italy

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  • Elena Germinario,

    Affiliation: Department of Human Anatomy and Physiology, University of Padova, Italy

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  • Katsumasa Goto,

    Affiliation: Department of Physiology, Graduate School of Health Sciences, Toyohashi Sozo University, Toyohashi-shi, Aichi, Japan

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  • Martina Gutsmann,

    Affiliation: Charité-Universitätsmedizin Berlin, Vegetative Anatomy and Zentrum für Weltraummedizin Berlin, Berlin, Germany

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  • Fuminori Kawano,

    Affiliation: Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan

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  • Naoya Nakai,

    Affiliation: Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan

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  • Takashi Ohira,

    Affiliation: Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan

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  • Yoshitaka Ohno,

    Affiliation: Department of Physiology, Graduate School of Health Sciences, Toyohashi Sozo University, Toyohashi-shi, Aichi, Japan

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  • Anne Picard,

    Affiliation: Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Michele Salanova,

    Affiliation: Charité-Universitätsmedizin Berlin, Vegetative Anatomy and Zentrum für Weltraummedizin Berlin, Berlin, Germany

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  • Gudrun Schiffl,

    Affiliation: Charité-Universitätsmedizin Berlin, Vegetative Anatomy and Zentrum für Weltraummedizin Berlin, Berlin, Germany

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  • Dieter Blottner,

    Affiliation: Charité-Universitätsmedizin Berlin, Vegetative Anatomy and Zentrum für Weltraummedizin Berlin, Berlin, Germany

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  • Antonio Musarò,

    Affiliation: DAHFMO-Unit of Histology and Medical Embryology, Sapienza University, IIM, Rome, Italy

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  • Yoshinobu Ohira,

    Affiliation: Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan

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  • Romeo Betto mail,

    romeo.betto@bio.unipd.it (RB); conte@farmbiol.uniba.it (DC); stefano.schiaffino@vimm.it (SS)

    Affiliation: National Research Council, Institute of Neuroscience, Padova, Italy

    These authors are joint senior authors on this work.

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  • Diana Conte mail,

    romeo.betto@bio.unipd.it (RB); conte@farmbiol.uniba.it (DC); stefano.schiaffino@vimm.it (SS)

    Affiliation: Section of Pharmacology, Department of Pharmacobiology, University of Bari, Italy

    These authors are joint senior authors on this work.

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  • Stefano Schiaffino mail

    romeo.betto@bio.unipd.it (RB); conte@farmbiol.uniba.it (DC); stefano.schiaffino@vimm.it (SS)

    Affiliation: Venetian Institute of Molecular Medicine, Padova, Italy

    These authors are joint senior authors on this work.

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  • Published: March 28, 2012
  • DOI: 10.1371/journal.pone.0033232
  • Published in PLOS ONE

About the Authors

Dorianna Sandonà, Elisa Bianchini, Anne Picard
Department of Biomedical Sciences, University of Padova, Padova, Italy
Jean-Francois Desaphy, Giulia M. Camerino, Diana Conte
Section of Pharmacology, Department of Pharmacobiology, University of Bari, Italy
Stefano Ciciliot, Daniela Danieli-Betto, Elena Germinario
Department of Human Anatomy and Physiology, University of Padova, Italy
Gabriella Dobrowolny, Antonio Musarò
DAHFMO-Unit of Histology and Medical Embryology, Sapienza University, IIM, Rome, Italy
Sandra Furlan, Romeo Betto
National Research Council, Institute of Neuroscience, Padova, Italy
Katsumasa Goto, Yoshitaka Ohno
Department of Physiology, Graduate School of Health Sciences, Toyohashi Sozo University, Toyohashi-shi, Aichi, Japan
Martina Gutsmann, Michele Salanova, Gudrun Schiffl, Dieter Blottner
Charité-Universitätsmedizin Berlin, Vegetative Anatomy and Zentrum für Weltraummedizin Berlin, Berlin, Germany
Fuminori Kawano, Naoya Nakai, Takashi Ohira, Yoshinobu Ohira
Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan
Stefano Schiaffino
Venetian Institute of Molecular Medicine, Padova, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JFD DB AM Y. Ohira RB DC SS. Performed the experiments: DS GMC EB SC DDB GD SF EG KG MG FK NN TO Y. Ohno AP MS GS. Analyzed the data: JFD DDB MS Y. Ohira KG RB. Contributed reagents/materials/analysis tools: JFD RB DC SS. Wrote the paper: RB.