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Research Article

Rational Diversification of a Promoter Providing Fine-Tuned Expression and Orthogonal Regulation for Synthetic Biology

  • Benjamin A. Blount,

    Affiliations: Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom, Department of Bioengineering, Imperial College London, London, United Kingdom

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  • Tim Weenink,

    Affiliation: Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom

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  • Serge Vasylechko,

    Affiliation: Department of Bioengineering, Imperial College London, London, United Kingdom

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  • Tom Ellis mail

    t.ellis@imperial.ac.uk

    Affiliations: Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom, Department of Bioengineering, Imperial College London, London, United Kingdom

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  • Published: March 19, 2012
  • DOI: 10.1371/journal.pone.0033279
  • Published in PLOS ONE

About the Authors

Benjamin A. Blount, Tim Weenink, Tom Ellis
Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom
Benjamin A. Blount, Serge Vasylechko, Tom Ellis
Department of Bioengineering, Imperial College London, London, United Kingdom

Corresponding Author

Email: t.ellis@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BAB TE. Performed the experiments: BAB TW SV. Analyzed the data: BAB TW SV. Wrote the paper: BAB TW TE.