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Research Article

Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era

  • Christine Carico,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Miriam Nuño,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Debraj Mukherjee,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Adam Elramsisy,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Jocelynn Dantis,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Jethro Hu,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Jeremy Rudnick,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • John S. Yu,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Keith L. Black,

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Serguei I. Bannykh,

    Affiliation: Department of Pathology, Division of Neuropathology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Chirag G. Patil mail

    chirag.patil@cshs.org

    Affiliation: Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pone.0033684
  • Published in PLOS ONE

About the Authors

Christine Carico, Miriam Nuño, Debraj Mukherjee, Adam Elramsisy, Jocelynn Dantis, Jethro Hu, Jeremy Rudnick, John S. Yu, Keith L. Black, Chirag G. Patil
Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Serguei I. Bannykh
Department of Pathology, Division of Neuropathology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Corresponding Author

Email: chirag.patil@cshs.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CP CC SB KB JH JR JY. Performed the experiments: SB CC MN DM AE JD JH CP. Analyzed the data: MN CC CP. Contributed reagents/materials/analysis tools: SB AE DM KB. Wrote the paper: CC CP MN JH JR JY KB SB DM.