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Research Article

Evaluation of Gene, Protein and Neurotrophin Expression in the Brain of Mice Exposed to Space Environment for 91 Days

  • Daniela Santucci,

    Affiliation: Behavioural Neuroscience Section, Cellular Biology and Neuroscience Department, Istituto Superiore di Sanità, Rome, Italy

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  • Fuminori Kawano,

    Affiliation: Graduate School of Medicine, Osaka University, Osaka, Japan

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  • Takashi Ohira,

    Affiliation: Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

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  • Masahiro Terada,

    Affiliation: Japan Aerospace Exploration Agency, Ibaraki, Japan

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  • Naoya Nakai,

    Affiliation: Graduate School of Medicine, Osaka University, Osaka, Japan

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  • Nadia Francia,

    Affiliation: Behavioural Neuroscience Section, Cellular Biology and Neuroscience Department, Istituto Superiore di Sanità, Rome, Italy

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  • Enrico Alleva,

    Affiliation: Behavioural Neuroscience Section, Cellular Biology and Neuroscience Department, Istituto Superiore di Sanità, Rome, Italy

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  • Luigi Aloe,

    Affiliation: Institute of Neurobiology and Molecular Medicine, CNR, European Brain Research Institute, Rome, Italy

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  • Toshimasa Ochiai,

    Affiliation: Mitsubishi Heavy Industries, Hyogo, Japan

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  • Ranieri Cancedda,

    Affiliation: DOBIG, University of Genova, Genova, Italy

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  • Katsumasa Goto,

    Affiliation: Graduate School of Health Sciences, Toyohashi SOZO University, Aichi, Japan

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  • Yoshinobu Ohira mail

    ohira@space.hss.osaka-u.ac.jp

    Affiliations: Graduate School of Medicine, Osaka University, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

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  • Published: July 09, 2012
  • DOI: 10.1371/journal.pone.0040112
  • Published in PLOS ONE

About the Authors

Daniela Santucci, Nadia Francia, Enrico Alleva
Behavioural Neuroscience Section, Cellular Biology and Neuroscience Department, Istituto Superiore di Sanità, Rome, Italy
Fuminori Kawano, Naoya Nakai, Yoshinobu Ohira
Graduate School of Medicine, Osaka University, Osaka, Japan
Takashi Ohira, Yoshinobu Ohira
Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
Masahiro Terada
Japan Aerospace Exploration Agency, Ibaraki, Japan
Luigi Aloe
Institute of Neurobiology and Molecular Medicine, CNR, European Brain Research Institute, Rome, Italy
Toshimasa Ochiai
Mitsubishi Heavy Industries, Hyogo, Japan
Ranieri Cancedda
DOBIG, University of Genova, Genova, Italy
Katsumasa Goto
Graduate School of Health Sciences, Toyohashi SOZO University, Aichi, Japan

Corresponding Author

Email: ohira@space.hss.osaka-u.ac.jp

Competing Interests

Toshimasa Ochiai is employed by Mitsubishi Heavy Industries. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RC YO. Performed the experiments: RC YO. Analyzed the data: DS FK T. Ohira MT NN NF EA LA T. Ochiai KG. Contributed reagents/materials/analysis tools: DS FK T. Ohira MT NN NF EA LA T. Ochiai KG. Wrote the paper: DS YO.