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Research Article

Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease

  • Alison R. Erickson equal contributor,

    equal contributor Contributed equally to this work with: Alison R. Erickson, Brandi L. Cantarel, Regina Lamendella, Claire M. Fraser, Robert L. Hettich

    Affiliations: Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America, Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, Tennessee, United States of America

    X
  • Brandi L. Cantarel equal contributor,

    equal contributor Contributed equally to this work with: Alison R. Erickson, Brandi L. Cantarel, Regina Lamendella, Claire M. Fraser, Robert L. Hettich

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Regina Lamendella equal contributor,

    equal contributor Contributed equally to this work with: Alison R. Erickson, Brandi L. Cantarel, Regina Lamendella, Claire M. Fraser, Robert L. Hettich

    Affiliation: Department of Ecology, Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    Current address: Juniata College, Biology Department, Huntingdon, Pennsylvania, United States of America

    X
  • Youssef Darzi,

    Affiliations: Bioinformatics and Eco-Systems Biology lab, Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium, Research Group of Microbiology (MICR), Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium

    X
  • Emmanuel F. Mongodin,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Chongle Pan,

    Affiliation: Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

    X
  • Manesh Shah,

    Affiliation: Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

    X
  • Jonas Halfvarson,

    Affiliation: Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital and School of Health and Medical Sciences, Örebro University, Örebro, Sweden

    X
  • Curt Tysk,

    Affiliation: Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital and School of Health and Medical Sciences, Örebro University, Örebro, Sweden

    X
  • Bernard Henrissat,

    Affiliation: Architecture et Fonction des Macromolécules Biologiques, UMR6098, Centre national de la recherche scientifique, Universités Aix-Marseille I & II, Marseille, France

    X
  • Jeroen Raes,

    Affiliations: Bioinformatics and Eco-Systems Biology lab, Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium, Research Group of Microbiology (MICR), Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium

    X
  • Nathan C. Verberkmoes,

    Affiliation: Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

    X
  • Claire M. Fraser equal contributor,

    equal contributor Contributed equally to this work with: Alison R. Erickson, Brandi L. Cantarel, Regina Lamendella, Claire M. Fraser, Robert L. Hettich

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    These authors are joint Senior Authors.

    X
  • Robert L. Hettich equal contributor,

    equal contributor Contributed equally to this work with: Alison R. Erickson, Brandi L. Cantarel, Regina Lamendella, Claire M. Fraser, Robert L. Hettich

    Affiliation: Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

    These authors are joint Senior Authors.

    X
  • Janet K. Jansson mail

    jrjansson@lbl.gov

    Affiliation: Department of Ecology, Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    These authors are joint Senior Authors.

    X
  • Published: November 28, 2012
  • DOI: 10.1371/journal.pone.0049138
  • Published in PLOS ONE

About the Authors

Alison R. Erickson, Chongle Pan, Manesh Shah, Nathan C. Verberkmoes, Robert L. Hettich
Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America
Alison R. Erickson
Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, Tennessee, United States of America
Brandi L. Cantarel, Emmanuel F. Mongodin, Claire M. Fraser
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Regina Lamendella, Janet K. Jansson
Department of Ecology, Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Youssef Darzi, Jeroen Raes
Bioinformatics and Eco-Systems Biology lab, Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
Youssef Darzi, Jeroen Raes
Research Group of Microbiology (MICR), Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium
Jonas Halfvarson, Curt Tysk
Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital and School of Health and Medical Sciences, Örebro University, Örebro, Sweden
Bernard Henrissat
Architecture et Fonction des Macromolécules Biologiques, UMR6098, Centre national de la recherche scientifique, Universités Aix-Marseille I & II, Marseille, France

Corresponding Author

Email: jrjansson@lbl.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKJ CMF RLH. Performed the experiments: JH CT RL BLC EFM ARE NCV. Analyzed the data: ARE BLC CP NCV RLH MS CP YD JR BH BLC. Wrote the paper: ARE BLC RL JKJ CMF RLH.