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Research Article

Therapeutic Subthalamic Nucleus Deep Brain Stimulation Reverses Cortico-Thalamic Coupling during Voluntary Movements in Parkinson's Disease

  • Josh Kahan mail,

    joshua.kahan@ucl.ac.uk

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Laura Mancini,

    Affiliations: Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom, Neuroradiological Academic Unit – Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

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  • Maren Urner,

    Affiliations: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, UCL Institute of Cognitive Neuroscience, University College London, London, United Kingdom

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  • Karl Friston,

    Affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

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  • Marwan Hariz,

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Etienne Holl,

    Affiliation: Department of Neurosurgery, Medical University of Graz, Graz, Austria

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  • Mark White,

    Affiliations: Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom, Neuroradiological Academic Unit – Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

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  • Diane Ruge,

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Marjan Jahanshahi,

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Tessel Boertien,

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Tarek Yousry,

    Affiliation: Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom

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  • John S. Thornton,

    Affiliations: Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom, Neuroradiological Academic Unit – Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

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  • Patricia Limousin,

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Ludvic Zrinzo,

    Affiliations: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom

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  • Tom Foltynie

    Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom

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  • Published: December 26, 2012
  • DOI: 10.1371/journal.pone.0050270
  • Published in PLOS ONE

About the Authors

Josh Kahan, Marwan Hariz, Diane Ruge, Marjan Jahanshahi, Tessel Boertien, Patricia Limousin, Ludvic Zrinzo, Tom Foltynie
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
Laura Mancini, Mark White, Tarek Yousry, John S. Thornton
Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom
Laura Mancini, Mark White, John S. Thornton
Neuroradiological Academic Unit – Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
Ludvic Zrinzo
Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery UCLH NHS Foundation Trust, London, United Kingdom
Maren Urner, Karl Friston
Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom
Maren Urner
UCL Institute of Cognitive Neuroscience, University College London, London, United Kingdom
Etienne Holl
Department of Neurosurgery, Medical University of Graz, Graz, Austria

Corresponding Author

Email: joshua.kahan@ucl.ac.uk

Competing Interests

TF, LZ, MH, and PL report that they have received honoraria from industry for invited talks. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The authors report that they have no other financial disclosures or conflicts of interest related to the topics addressed in the study.

Author Contributions

Conceived and designed the experiments: TF PL LZ MJ JT TB MH. Performed the experiments: LM JK MW DR JT TF. Analyzed the data: JK MU LM KF. Contributed reagents/materials/analysis tools: MU KF MW TY JT EH. Wrote the paper: JK TF KF.