Advertisement
Research Article

Hypothesis Testing and Power Calculations for Taxonomic-Based Human Microbiome Data

  • Patricio S. La Rosa,

    Affiliation: Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • J. Paul Brooks,

    Affiliation: Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Elena Deych,

    Affiliation: Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Edward L. Boone,

    Affiliation: Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • David J. Edwards,

    Affiliation: Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Qin Wang,

    Affiliation: Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Erica Sodergren,

    Affiliation: The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • George Weinstock,

    Affiliation: The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • William D. Shannon mail

    wshannon@wustl.edu

    Affiliation: Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Published: December 20, 2012
  • DOI: 10.1371/journal.pone.0052078
  • Published in PLOS ONE

About the Authors

Patricio S. La Rosa, Elena Deych, William D. Shannon
Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
J. Paul Brooks, Edward L. Boone, David J. Edwards, Qin Wang
Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
Erica Sodergren, George Weinstock
The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: wshannon@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GW ES. Performed the experiments: GW ES. Analyzed the data: PSL ED WDS. Wrote the paper: PSL WDS. Design Statistical Methods: PSL JPB ELB DJE QW WDS. Design Software: PSL ED WDS.