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Research Article

A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity

  • Ayala Tovy,

    Affiliation: Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

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  • Rama Siman Tov,

    Affiliation: Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

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  • Ricarda Gaentzsch,

    Affiliation: Department of Chemistry, The Pharmacy and Molecular Biotechnology Institute, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany

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  • Mark Helm,

    Affiliations: Department of Chemistry, The Pharmacy and Molecular Biotechnology Institute, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany, The Pharmacy and Biochemistry Institute, Johannes Gutenberg University, Mainz, Germany

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  • Serge Ankri mail

    sankri@tx.technion.ac.il

    Affiliation: Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

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  • Published: February 19, 2010
  • DOI: 10.1371/journal.ppat.1000775
  • Published in PLOS Pathogens

About the Authors

Ayala Tovy, Rama Siman Tov, Serge Ankri
Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
Ricarda Gaentzsch, Mark Helm
Department of Chemistry, The Pharmacy and Molecular Biotechnology Institute, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany
Mark Helm
The Pharmacy and Biochemistry Institute, Johannes Gutenberg University, Mainz, Germany

Corresponding Author

Email: sankri@tx.technion.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AT SA. Performed the experiments: AT RST SA. Analyzed the data: AT MH SA. Contributed reagents/materials/analysis tools: RG MH. Wrote the paper: AT SA.