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Research Article

Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae

  • Grant L. Hughes,

    Affiliations: The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, The Johns Hopkins Malaria Research Institute, Baltimore, Maryland, United States of America

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  • Ryuichi Koga,

    Affiliation: National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

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  • Ping Xue,

    Affiliations: The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, The Johns Hopkins Malaria Research Institute, Baltimore, Maryland, United States of America

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  • Takema Fukatsu,

    Affiliation: National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

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  • Jason L. Rasgon mail

    jrasgon@jhsph.edu

    Affiliations: The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, The Johns Hopkins Malaria Research Institute, Baltimore, Maryland, United States of America

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  • Published: May 19, 2011
  • DOI: 10.1371/journal.ppat.1002043
  • Published in PLOS Pathogens

About the Authors

Grant L. Hughes, Ping Xue, Jason L. Rasgon
The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Grant L. Hughes, Ping Xue, Jason L. Rasgon
The Johns Hopkins Malaria Research Institute, Baltimore, Maryland, United States of America
Ryuichi Koga, Takema Fukatsu
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

Corresponding Author

Email: jrasgon@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GLH JLR. Performed the experiments: GLH RK PX. Analyzed the data: GLH RK TF JLR. Contributed reagents/materials/analysis tools: GLH RK TF JLR. Wrote the paper: GLH RK TF JLR.