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Research Article

Host Genes Related to Paneth Cells and Xenobiotic Metabolism Are Associated with Shifts in Human Ileum-Associated Microbial Composition

  • Tianyi Zhang,

    Affiliations: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America

    X
  • Robert A. DeSimone,

    Affiliation: Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America

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  • Xiangmin Jiao,

    Affiliation: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America

    X
  • F. James Rohlf,

    Affiliation: Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York, United States of America

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  • Wei Zhu,

    Affiliation: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America

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  • Qing Qing Gong,

    Affiliation: Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Steven R. Hunt,

    Affiliation: Department of Surgery, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Themistocles Dassopoulos,

    Affiliation: Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

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  • Rodney D. Newberry,

    Affiliation: Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

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  • Erica Sodergren,

    Affiliation: The Genome Institute, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

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  • George Weinstock,

    Affiliation: The Genome Institute, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

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  • Charles E. Robertson,

    Affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America

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  • Daniel N. Frank,

    Affiliation: Department of Medicine, University of Colorado, Aurora, Colorado, United States of America

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  • Ellen Li mail

    Ellen.Li@stonybrook.edu

    Affiliations: Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Published: June 13, 2012
  • DOI: 10.1371/journal.pone.0030044
  • Published in PLOS ONE

About the Authors

Tianyi Zhang, Xiangmin Jiao, Wei Zhu
Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America
Tianyi Zhang, Robert A. DeSimone, Ellen Li
Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
F. James Rohlf
Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York, United States of America
Qing Qing Gong, Themistocles Dassopoulos, Rodney D. Newberry, Ellen Li
Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America
Steven R. Hunt
Department of Surgery, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America
Erica Sodergren, George Weinstock
The Genome Institute, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America
Charles E. Robertson
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America
Daniel N. Frank
Department of Medicine, University of Colorado, Aurora, Colorado, United States of America

Corresponding Author

Email: Ellen.Li@stonybrook.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRH TD RDN DNF EL. Performed the experiments: QG GW ES. Analyzed the data: TZ RAD XJ FJR WZ CER DNF EL. Contributed reagents/materials/analysis tools: TZ XJ SRH TD RDN CER DNF EL. Wrote the paper: TZ RAD XJ FJR WZ QG SRH TD RDN GW ES CER DNF EL.