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Research Article

Bacterial Communities in Women with Bacterial Vaginosis: High Resolution Phylogenetic Analyses Reveal Relationships of Microbiota to Clinical Criteria

  • Sujatha Srinivasan mail,

    dfredric@fhcrc.org (DNF); ssriniva@fhcrc.org (SS)

    Affiliation: Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Noah G. Hoffman,

    Affiliation: Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America

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  • Martin T. Morgan,

    Affiliation: Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Frederick A. Matsen,

    Affiliation: Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Tina L. Fiedler,

    Affiliation: Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Robert W. Hall,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Frederick J. Ross,

    Affiliation: Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Connor O. McCoy,

    Affiliation: Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Roger Bumgarner,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Jeanne M. Marrazzo,

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • David N. Fredricks mail

    dfredric@fhcrc.org (DNF); ssriniva@fhcrc.org (SS)

    Affiliations: Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: June 18, 2012
  • DOI: 10.1371/journal.pone.0037818
  • Published in PLOS ONE

About the Authors

Sujatha Srinivasan, Tina L. Fiedler, David N. Fredricks
Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Noah G. Hoffman
Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
Martin T. Morgan, Frederick A. Matsen, Frederick J. Ross, Connor O. McCoy
Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Robert W. Hall, Roger Bumgarner, David N. Fredricks
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Jeanne M. Marrazzo, David N. Fredricks
Department of Medicine, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

D. N. Fredricks and T. L. Fiedler have developed intellectual property related to the use of PCR for the diagnosis of BV. Refer to US patent 7625704 on use of PCR for diagnosis of BV. No products to report. David Fredricks is a PLoS ONE editorial board member. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SS JMM DNF. Performed the experiments: TLF RWH. Analyzed the data: SS NGH MTM FAM FJR COM. Contributed reagents/materials/analysis tools: NGH MTM FAM RB DNF. Wrote the paper: SS NGH MTM FAM JMM DNF.